Referenze Bibliografiche Libro “Come Vivere fino a 150 anni”

Il libro “Come vivere 150 anni” del Dr. Tsoukalas fa riferimento a innumerevoli ricerche in ambito scientifico e medico.

Sarebbe stato impossibile includere nel libro tutti i riferimenti bibliografici a cui esso attinge.

In questa pagina daremo alcuni approfondimenti sugli argomenti toccati nel volume e forniremo la vasta bibliografia associata.


Capitolo 1

voci su: (versione inglese)

– “pleasure” (piacere)

– “thermodynamics” (termodinamica)

– “primum non nocere”

Articolo su “Does nature break the second law of thermodynamics?

Citazioni di Voltaire su:

Capitolo 2

The Biology of Belief” Bruce H. Lipton Ph.D 2005

Capitolo 3

The new science of ageing Linda Partridge, Janet Thornton and Gillian Bates Phil. Trans. R. Soc. B 2011 366, 6-8 doi: 10.1098/rstb.2010.0298

Less Is More How Less Health Care Can Result in Better Health Arch Intern Med. 2010;170(9):749-750

An Analysis of the Relationship Between Metabolism,Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts. Joa˜o Pedro de Magalha ˜es,1 Joana Costa,2 and George M. Church1

Journal of Gerontology: BIOLOGICAL SCIENCES 2007, Vol. 62A, No. 2, 149–160

Capitolo 4

WHO Technical Report Series, 916. Diet, Nutrition and the Prevention of Chronic Diseases (2003 : Geneva, Switzerland)

TH Tulchinsky. Micronutrient deficiency conditions: global health issues. Public Health Reviews 2010;32:243- 255.

Bruce N. Ames. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. PNAS, November 21, 2006. vol. 103

Phyllis A. Balch. Prescription for Dietary Wellness, Penguin publications group 2003.

From Rio to Rio+20: Progress and Challenges since the 1992 Earth Summit United Nations Conference on Sustainable Development United Nations Department of Public Information, June 2012

A key regulatory role for histamine in autoimmune encephalomyelitis Transdermal histamine in multiple sclerosis

How does exercise cause asthma attacks?

Selenium, selenoproteins and the thyroid gland

Brain-gut-microbe communication in health and disease

Vitamin D for Cancer Prevention J Epidemiology 2009

Vitamin D and prevention of breast cancer

Vitamin D and prevention of colorectal cancer

Recurrent aphthous stomatitis of any origin with vitamin B12

Trends Of food Intake USDA

Recent exposure to fine particle pollution linked to lupus disease activityJennifer F. Nyland and Wendy Hessler,

Environmental Health News, November 11, 2010

Elias K, et al. Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat- 5 independent signaling pathway. Blood 2008;111:1013-1020.

High Intake of Vitamin D Linked to Reduced Risk of Multiple Sclerosis, InteliHealth, Jan. 12, 2004;

Capitolo 5

Radzicka A, Wolfenden R. (1995). “A proficient enzyme“. Science 267 (5194): 90–931. doi:10.1126/science.7809611. PMID 7809611.

Capitolo 6

Radzicka A, Wolfenden R. (1995). “A proficient enzyme“. Science 267 (5194): 90–931. doi:10.1126/science.7809611. PMID 7809611.

Healthy Living Is the Best Revenge Findings From the European Prospective Investigation Into Cancer and Nutrition–Potsdam StudyEarl S. Ford, MD, MPH;Manuela M. Bergmann, PhD; Janine Kröger; Anja Schienkiewitz, PhD, MPH; Cornelia Weikert, MD, MPH; Heiner Boeing, PhD, MSPH. ARCH INTERN MED/VOL 169 (NO. 15), AUG 10/24, 2009

Genomics Is Not Enough Metabolomics Vol. 1, No. 1, January 2005

Laboratory Evaluations for Int. and Functional Med 2nd Edition 2008/ R Lord and J Bralley

The American Society for Nutritional Sciences J. Nutr. 132:2486-2487, September 2002

J Am Diet Assoc. 2005 Sep;105(9):1425-32

Curr Opin Clin Nutr Metab Care. 2009 Sep;12(5):501-7

Ital J Pediatr. 2009; 35: 30

Mitochondrial dysfunction and molecular pathways of disease, S. Pieczenik J. Neustadt, Science Direct EMPJ 2007

Curr Opin Endocrinol Diabetes Obes. 2010

Oct;17(5):446-52 Mitochondrial dysfunction in obesity

Capitolo 8

Capitolo 9

Artemis P. Simopoulos. The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases. Experimental Biology and Medicine 2008, 233:674-688. doi: 10.3181/0711-MR-311 L Ron Hubbard. Clear Body Clear Mind Bridge Publications 1990, Bridge Publications

Cox BD, Whichelow MJ. Frequent consumption of red meat is not a risk factor for cancer. Br Med J 1997, 315: 1018

Carroll K K. Dietary fats and cancer. Am J Clin Nutr 1991,53: 1064S

Capitolo 10 term = + vitamina D

Assessing Vitamin D status JCNutrition 2011

La vitamina D per la prevenzione del cancro J Epidemiology 2009

Vitamina D e prevenzione del cancro al seno

Vitamina D e prevenzione del cancro del colon-retto

Capitolo 11

Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. Bioessays 00: 000–000,ß 2011 WILEY Periodicals, Inc.

Intestinal hyperpermeability and associated diseases CLINICS 2010;65(6):635-43 Rapin JR et al.

J Clin Gastroenterol. 2002 Apr;34(4):385-96. Intestinal permeation and gastrointestinal disease. DeMeo MT, Mutlu EA, Keshavarzian A, Tobin MC.

Capitolo 12

Positive emotions in early life and longevity: findings from the nunstudy. Danner DD, Snowdon DA, Friesen WV. J Pers Soc Psychol.  2001 May;80(5):804-13.

The autoimmune epidemic. Donna Jackson Nakazawa. Simon & Schuster 2003.

Cell Damage and Autoimmunity Colloquium draws internationally known researchers

Significant association shown between vitamin D and autoimmune diseases

Vitamin A and Anti-Inflammatory Activity

Polyunsaturated fatty acids, membrane organization, Tcells, and antigen presentation1–3. Saame Raza Shaikh and Michael Edidin. Am J Clin Nutr 2006;84:1277–89

Capitolo 13;2-J/pdf

Impact of antioxidant supplementation on chemotherapeutic toxicity: A systematic review of the evidence from randomized controlled trials. Keith I. Block1,2, Amanda C. Koch1,2*, Mark N. Mead1, Peter K. Tothy1, Robert A. Newman3 and Charlotte Gyllenhaal1,2. Int. J. Cancer: 123, 1227–1239 (2008) ‘ 2008Wiley- Liss,Inc.

Impact of antioxidant supplementation on chemotherapeutic efficacy: A systematic review of the evidence from randomized controlled trials Cancer Treatment Reviews Volume 33, Issue 5 , Pages 407-418, August 2007 Riordan HD, Hunninghake RB, Riordan NH, et al. Intravenous ascorbic acid: protocol for its application and use. P R Health Sci J. 2003 Sep;22(3):287-90.

Bowie AG, O’Neill LA. Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase. J Immunol. 2000 Dec 15;165(12):7180-8.

Ahsan H, Parveen N, Khan NU, et al. Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. Chem Biol Interact. 1999 Jul 1;121(2):161-75.

Arbiser JL, Klauber N, Rohan R, et al. Curcumin is an in vivo inhibitor of angiogenesis. Mol Med. 1998 Jun;4(6):376-83.

Jee SH, Shen SC, Tseng CR, et al. Curcumin induces a p53- dependent apoptosis in human basal cell carcinoma cells. J Invest Dermatol. 1998 Oct;111(4):656-61.

Li JK, Lin-Shia SY. Mechanisms of cancer chemoprevention by curcumin. Proc Natl Sci Counc Repub China B. 2001 Apr;25 (2):59- 66.

Plummer SM, Holloway KA, Manson MM, et al. Inhibition of cyclo- oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene. 1999 Oct 28;18 (44):6013-20.

Ruby AJ, Kuttan G, Babu KD, et al. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett. 1995 Jul 20;94 (1):79- 83.

Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.

Hosoe K, Kitano M, Kishida H, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28.

Exp Gerontol. 2006 Feb;41(2):130-40.

Int J Food Sci Nutr. 2006 Nov-Dec;57(7-8):546-55.

Capitolo 14

Virchow, Rudolf (1856). “Gesammelte Abhandlungen zur wissenschaftlichen Medizin“. Germany: Staatsdruckerei Frankfurt. Phlogose und Thrombose im Gefäßsystem.

Anitschkow NN, Chatalov S (1913). “Über experimentelle Cholesterinsteatose und ihre Bedeutung für die Entstehung einiger pathologischer Prozesse“. Zentralbl Allg Pathol 24: 1–9.

The cholesterol delusion. 2010 Ernest Curtis MD 

Am J Cardiovasc Drugs. 2008;8(6):373-418. doi: 10.2165/0129784-200808060-00004.

Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism. Golomb BA, Evans MA. Department of Medicine, University of California, San Diego, California.

Cholesterol in the Prediction of Atherosclerotic Disease New Perspectives Based on the Framingham Study. Annals of Internal Medicine 90:85-91, 1979

Sever PS, Dahlöf P, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003; 361: 1149-1158

The American Journal of Medicine Volume 116, Issue 3 , Pages 158-164, 1 February 2004.

Effect of folic acid fortification of food on homocysteine-related mortality Circulation:Volume 92(10)15 November 1995pp 2825-2830

Hyperhomocysteinemia and Low Pyridoxal Phosphate: Common and Independent Reversible Risk Factors for Coronary Artery Disease

The Treatment of Hyperhomocysteinemia Bradley A. Maron, M.D. and Joseph Loscalzo, M.D., PhD. From the Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

 Harvard School of Medicine, Change in Thinking about Cholesterol

Inflammation in the vascular bed: importance of vitamin C. Aguirre R, May JM. Pharmacol Ther. 2008 Jul;119(1):96-103. doi:10.1016/j.pharmthera.2008.05.002. Epub 2008 May 28.

A Unified Theory of Human Cardiovascular Disease Leading the Way to the Abolition of This Disease as a Cause for Human Mortality Matthias Rath M.D. and Linus Pauling Ph.D. Journal of Orthomolecular Medicine Vol. 7, No. 1, 1992

Ascorbic acid and atherosclerotic cardiovascular disease. Lynch SM, Gaziano JM, Frei B. Whitaker Cardiovascular Institute, Boston University School of Medicine, Massachusetts 02118-2394, USA. Subcell Biochem. 1996;25:331-67.

Ascorbic acid synthesis due to L-gulono-1,4-lactone oxidase expression enhances NO production in endothelial cells. Kim, H.J., Lee, S.I., Lee, D.H., Smith, D., Jo, H., Schellhorn, H.E., Boo, Y.C. Biochem. Biophys. Res. Commun. (2006)

Leitch, I. (1942) The evolution of dietary standards. Nutr. Abs. Rev.11:509-521

Effect of the Magnitude of Lipid Lowering on Risk of Elevated Liver Enzymes, Rhabdomyolysis, and Cancer: Insights From Large Randomized Statin Trials Journal of the American College of Cardiology Volume 50, Issue 5, 31 July 2007. Tufts University School of Medicine, Boston, Massachusetts.

Dietary Intake of Menaquinone Is Associated with a Reduced Risk of Coronary Heart Disease: The Rotterdam Study. J. Nutr. November 1, 2004 vol. 134 no. 11 3100-3105


Capitolo 15

The Rosedale Diet William Morrow; 1 edition August 31, 2004$=relatedreviews&logdbfrom=pubmed

Vitamin K2 supplementation improves insulin sensitivity via osteocalcin metabolism: a placebo-controlled trial. Diabetes Care.2011 Sep;34(9)

Dietary phylloquinone and menaquinones intake and risk of type 2 diabetes Diabetes Care April 27, 2010

Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003 Dec;26(12):3215-8.

Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet Med. 2010 Oct;27(10):1159-67.

Capitolo 16

Caloric restriction and aging: studies in mice and monkeys. Anderson RM, Shanmuganayagam D, Weindruch R. Toxicol Pathol. 2009 Jan;37(1):47-51.

Caloric restriction in primates. Lane MA, Black A, Handy A, Tilmont EM, Ingram DK, Roth GS. Ann N Y Acad Sci. 2001 Apr;928:287-95.

Diet and aging. Ribarič S. Oxid Med Cell Longev. 2012;2012:741468.

Alternate-day fasting and chronic disease prevention: a review of human and animal trials1–3 Krista A Varady and Marc K Hellerstein. Am J Clin Nutr 2007;86:7–13

Improvements in Coronary Heart Disease Risk Indicators by Alternate-Day Fasting Involve Adipose Tissue Modulations Surabhi Bhutani1, Monica C. Klempel1, Reed A. Berger2 and Krista A. Varady1. Obesity (2010) doi:10.1038/oby.2010.54

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity David R. Clemmons J Clin Invest. 2004 January 1; 113(1): 25–27.

A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Zhou Y, Xu BC, Maheshwari HG, He L, Reed M, Lozykowski M, Okada S, Cataldo L, Coschigamo K, Wagner TE, Baumann G, Kopchick JJ. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13215-20.

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans”. Guevara-Aguirre, J; Balasubramanian, P; Guevara-Aguirre, M; Wei, M; Madia, F; Cheng, CW; Hwang, D; Martin-Montalvo, A et al. (2011). Science Translational Medicine 3 (70): 70ra13.

Ecuadorean Villagers May Hold Secret to Longevity.  Wade, Nicholas (17 February 2011). The New York Times. ISSN 0362-4331. Retrieved 17 February 2011.

“Defective Growth Gene in Rare Dwarfism Disorder Stunts Cancer and Diabetes”. Bai, Nina.Scientific American. Retrieved 17 February 2011.

Insulin resistance, its metabolic effects. Dr. Ron Rosedale.

Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy. Science Translational Medicine. February 8 2012.

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. C Lee and V D Longo. Oncogene 30, 3305-3316 (28 July 2011)

Weston Price Nutrition and Physical Degeneration 1938

Roger Williams Biochemical Individuality 1998

Capitolo 17

Leitch, I. (1942) The evolution of dietary standards. Nutr. Abs. Rev. 11:509-521

History of Nutrition Standars New RDAs / / wiki / Vitamin_poisoning # cite_note-

Capitolo 18

Nguyen, D.T., Orgill D.P., Murphy G.F. (2009). Chapter 4: The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration

Nature: Metabolic Effects of Mental Stress during Over- and Underfeeding in Healthy Women Review Article 1537-744X; DOI 10.1100/tsw.2005.16

The Stress of Life. New York, McGrawHill, 1956. Rev. ed. 1976.

Selye Circulation: Mental Stress Induces Transient Endothelial Dysfunction in Humans TheScientificWorldJOURNAL (2005) 5, 93–102 ISSN

Effect of mental stress throughout the day on cardiac autonomic control

Capitolo 20

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